2010 MotoGP şampiyonasında yarışacak isimler belli oldu.
FB Corse ile John Hopkins bu seneki listede yer almıyor.

• 4 Andrea Dovizioso Repsol Honda Team Honda
• 5 Colin Edwards Monster Yamaha Tech 3 Yamaha
• 7 Hiroshi Aoyama Interwetten-Honda MotoGP Honda
• 11 Ben Spies Monster Yamaha Tech 3 Yamaha
• 14 Randy de Puniet LCR Honda MotoGP Honda
• 19 Alvaro Bautista Rizla Suzuki MotoGP Suzuki
• 24 Marco Melandri San Carlo Honda Gresini Honda
• 26 Dani Pedrosa Repsol Honda Team Honda
• 27 Casey Stoner Ducati Marlboro Team Ducati
• 36 Mika Kallio Pramac Racing Team Ducati
• 40 Hector Barbera Aspar MotoGP Team Ducati
• 41 Aleix Espargaro Pramac Racing Team Ducati
• 46 Valentino Rossi Fiat Yamaha Team Yamaha
• 58 Marco Simoncelli San Carlo Honda Gresini Honda
• 65 Loris Capirossi Rizla Suzuki MotoGP Suzuki
• 69 Nicky Hayden Ducati Marlboro Team Ducati
• 99 Jorge Lorenzo Fiat Yamaha Team Yamaha